antiseizurepharm.com https://antiseizurepharm.com Wed, 16 Feb 2022 08:14:52 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.5 https://antiseizurepharm.com/wp-content/uploads/logos/cropped-logo-9614357-1-32x32.png antiseizurepharm.com https://antiseizurepharm.com 32 32 All about cholesterol: the rate in the blood, how to reduce https://antiseizurepharm.com/useful-information/all-about-cholesterol-the-rate-in-the-blood-how-to-reduce/ Wed, 21 Jul 2021 00:00:00 +0000 https://antiseizurepharm.com/?p=317 There is a widespread misconception that cholesterol is harmful to the body, and its content in the blood is one of the most important indicators of human health. Many, in an attempt to maintain their health, adhere to strict diets, excluding all foods containing cholesterol. However, few people know that it is part of cell… Read More »All about cholesterol: the rate in the blood, how to reduce

The post All about cholesterol: the rate in the blood, how to reduce first appeared on antiseizurepharm.com.

]]>
There is a widespread misconception that cholesterol is harmful to the body, and its content in the blood is one of the most important indicators of human health. Many, in an attempt to maintain their health, adhere to strict diets, excluding all foods containing cholesterol. However, few people know that it is part of cell membranes, gives them strength and ensures the exchange of substances between the cell and the extracellular substance and regulates the activity of enzymes. Thus, normal functioning of our body is impossible without cholesterol.

Despite the importance of cholesterol, excessive consumption of fatty foods of animal origin can lead to an increased content in the body, which negatively affects health and can cause serious illness .

Controlling cholesterol levels will help maintain your health or many years, increase the body’s natural resistance, increase life expectancy and improve its quality. In this article, we will dispel the most common myths about the role of cholesterol in our body and its metabolism. We will also look at the most effective ways to control cholesterol levels.

Cholesterol – why is it needed?

Cholesterol (from the Greek chole – bile and stereo – hard, hard) – was first identified in gallstones from here and got its name. It is a naturally occurring, water-insoluble lipophilic alcohol. About 80% of cholesterol is synthesized in the body (liver, intestines, kidneys, adrenal glands, sex glands), the remaining 20% ​​must come from the food we eat.

Circulating in the bloodstream, cholesterol, if necessary, is used as a building material, as well as for the synthesis of more complex compounds. Since it is insoluble in water (and, accordingly, in blood), its transportation is possible only in the form of complex water-soluble compounds, which are divided into 2 types:

  • Low density lipoproteins (LDL)
  • High density lipoproteins (HDL)

Both of these substances should be in a strictly defined ratio, their total volume should also not exceed the norm. This can lead to serious diseases of the cardiovascular system.

Cholesterol functions in the body

  • ensuring the strength of cell walls, regulating their permeability for various molecules;
  • synthesis of vitamin D;
  • synthesis of the adrenal glands of steroid (cortisone, hydrocortisone), male (androgens) and female (estrogen, progesterone) sex hormones;
  • in the form of bile acids, it participates in the formation of bile and the absorption of fats during digestion;
  • participates in the formation of new synapses in the brain, thereby improving mental abilities and memory.

In fact, it is not cholesterol as such that causes harm, but its fluctuations beyond the normal range. Health problems can be caused by both excess and lack of it in the body.

The negative effects of cholesterol

According to statistics, people who died from cardiovascular disease had low levels of high density lipoproteins, but high levels of low density lipoproteins.

Lipoproteins, with an incorrect ratio or prolonged elevated levels in the blood, can settle on the walls of blood vessels and cause atherosclerosis.

This dangerous disease occurs when plaques form on the vascular endothelium, which grow more and more over time and accumulate calcium. As a result, the lumen of the vessels narrows, they lose elasticity (stenosis), this leads to a decrease in the supply of oxygen and nutrients to the heart and tissues and the development of angina pectoris (cessation of the supply of arterial blood to certain parts of the heart due to blockage of the coronary artery, accompanied by pain and discomfort in the chest) … Often it is due to a violation of the blood supply that a heart attack or myocardial infarction occurs. The formation of cholesterol plaques leads to damage on the inner wall of blood vessels, a blood clot may form, which can subsequently block an artery or break off and cause an embolism. Also, a vessel that has lost its elasticity can burst when the pressure in the bloodstream rises.

The role of lipoproteins

HDL is considered a “good” lipoprotein due to its ability to dissolve plaque from cholesterol and remove it from the walls of arteries, the higher its percentage in relation to LDL (“bad” lipoprotein), the better. LDL transports cholesterol from the organs synthesizing it into the arteries, and with an increased content of this compound, these large insoluble molecules combine in the form of fatty plaques, attach to the vessels and clog them. Having undergone oxidative processes, cholesterol loses its stability and can easily penetrate into the thickness of the walls of the arteries.

Specific antibodies are produced on the formed oxidized LDL in large quantities, which leads to severe damage to the walls of the arteries. In addition, cholesterol helps lower nitric oxide levels, increasing the risk of developing cardiovascular disease.

Nitric oxide plays an important role in the body

  • dilates blood vessels, lowers blood pressure, prevents blood clots;
  • plays an important role in the fight against bacteria and viruses that have entered the body, destroys cancer cells;
  • increases the endurance of muscle tissue;
  • participates in the exchange of information between various cells, is a neurotransmitter in synapses.

A decrease in the level of nitrous oxide in the body will undermine the work of all body systems.

HDL not only removes cholesterol from the blood back to the liver, but also prevents the oxidation of LDL .

Signs of increased cholesterol levels in the body

Increased cholesterol levels are associated with lipid disorders (fat) metabolism. This can be a symptom of not only atherosclerosis, but also other serious diseases:

  • liver;
  • kidney (chronic renal failure, glomerulonephritis);
  • pancreas glands (chronic pancreatitis);
  • diabetes mellitus (a serious illness associated with impaired insulin synthesis by beta cells of the islets of Langerhans in the pancreas);
  • hypothyroidism (decreased synthesis of thyroid hormones);
  • obesity .

Symptoms of atherosclerosis are caused by narrowing of the vascular lumen as a result of prolonged and persistent high cholesterol levels, and impaired blood circulation in different parts of the bloodstream.

Main symptoms

  • angina (sudden discomfort or pain in the chest that occurs during physical exertion or emotional stress);
  • shortness of breath;
  • arrhythmia (heart rhythm disturbance);
  • cyanosis and swelling of peripheral parts of the body (fingers, toes) ;
  • recurrent leg cramps (intermittent claudication);
  • memory impairment, inattention;
  • intellectual decline;
  • yellow-pink lipid deposits in the skin (xanthomas), most often seen on the skin of the eyelids and ankle joints.

Effect of HDL and LDL levels on our health

Still, the opinion that the total level of HDL and LDL lipoproteins affects the state of health and their increase entails terrible consequences for the work of the whole organism. However, this statement is not entirely true. Yes, the above diseases will be accompanied by an increased content of lipoproteins in general, but it is much more important, what is the ratio of “good” HDL to “bad” LDL in the blood. It is the violation of this proportion that leads to health problems. When determining the content of lipoproteins in the blood, 4 indicators are taken into account: total cholesterol, HDL, LDL and triglyceride levels.

Norms

Total cholesterol in the blood – 3.0 – 5.0 mmol / l;

With the threat of atherosclerosis, total cholesterol rises to 7.8 mmol / l;

LDL in men – 2.25 – 4.82 mmol / l;

LDL in women – 1.92 – 4.51 mmol / L;

HDL in men – 0.72 – 1.73 mmol / l;

HDL in women – 0.86 – 2.28 mmol / l;

Triglycerides in men – 0.52 – 3.7 mmol / l;

Triglycerides in women – 0.41 – 2.96 mmol / l.

The most indicative is the ratio of HDL and LDL against the background of total cholesterol levels. In a healthy body, HDL is much higher than LDL.

The most effective treatments for high cholesterol

There are many drugs that lower cholesterol levels in cases where this level poses a serious threat to health, or at the beginning of the development of atherosclerosis. It is necessary to pay tribute to a healthy lifestyle, an important part of which is proper nutrition. In such cases, diet and moderate physical activity will help not only bring all blood counts back to normal, but also completely heal and rejuvenate your body.

For a faster therapeutic effect, pharmacological drugs are used:

– Statins – the most popular drugs, their principle of action is to inhibit the synthesis of cholesterol in the liver by blocking the corresponding enzymes. Usually they are taken once a day before bedtime (at this time, active production of cholesterol in the body begins). The therapeutic effect occurs after 1-2 weeks of systematic intake, with prolonged use they do not cause addiction. Side effects may include nausea, pain in the abdomen and muscles, in rare cases, there may be individual sensitivity. The drugs of the statin group can reduce cholesterol levels by 60%, but if they are taken for a long time, it is necessary to take tests for AST and ALT regularly every six months. The most common statins: cerivastatin, fluvastatin, lovastatin.

– Fibrates stimulate the production of HDL, recommended for triglycerides of 4.5 mmol / L. It is highly discouraged for use with statins. Side effects are manifested in the form of gastrointestinal disorders, flatulence, nausea, vomiting, and abdominal pain. Representatives of this group of drugs: clofibrate, fenofibrate, gemfibrozil.

– Bile acid sequestrants. This group of drugs is not absorbed into the bloodstream, but acts locally – it binds to bile acids, which are synthesized from cholesterol, and remove them from the body naturally. The liver begins an increased production of bile acids, using a larger amount of cholesterol from the blood, a visible positive effect occurs a month after the start of medication, to enhance the effect, it is possible to take statins at the same time. Long-term use of drugs can lead to impaired absorption of fats and vitamins, increased bleeding is possible. Side effects: flatulence, constipation. These drugs include: colestipol, cholestyramine.

– Cholesterol absorption inhibitors prevent the absorption of lipids from the intestine. Drugs in this group can be prescribed to people who have contraindications to taking statins, since they are not absorbed into the bloodstream. In Russia, only 1 drug of the group of cholesterol absorption inhibitors is registered – ezetrol.

The above measures are used in advanced cases when it is necessary to quickly reduce cholesterol levels, and a change in lifestyle cannot quickly give the desired effect. But even when taking pharmacological agents, do not forget about prevention, and harmless natural supplements, which, with long-term regular use, will help you prevent diseases of the cardiovascular system in the future.

The post All about cholesterol: the rate in the blood, how to reduce first appeared on antiseizurepharm.com.

]]>
Stretching your muscles after exercise https://antiseizurepharm.com/exercises/stretching-your-muscles-after-exercise/ Wed, 14 Jul 2021 00:00:00 +0000 https://antiseizurepharm.com/?p=277 The main purpose of stretching is to intentionally lengthen the tendons and muscle tissue. This is not the only purpose of this exercise. It helps to strengthen and grow muscles. Performing it regularly makes you more flexible, improves your well-being and helps you find the right posture. Stretching well after a workout reduces the likelihood… Read More »Stretching your muscles after exercise

The post Stretching your muscles after exercise first appeared on antiseizurepharm.com.

]]>
The main purpose of stretching is to intentionally lengthen the tendons and muscle tissue. This is not the only purpose of this exercise. It helps to strengthen and grow muscles. Performing it regularly makes you more flexible, improves your well-being and helps you find the right posture. Stretching well after a workout reduces the likelihood of injury. Without performing this exercise, it is impossible to talk about the correct completion of a workout in the gym.

When and why to stretch the muscles?

Stretching exercises are performed after the completion of the main workout. This is due to the fact that after active physical muscles are fully warmed up and ready to stretch. You can do stretching as the final element of the warm-up, but it is of great benefit at the end of the lesson. This exercise cannot be ignored because it makes muscles more elastic and flexible, helps to increase the volume and strengthen muscle tissue.

Stretching has a multifaceted positive effect:

  • Opens up more strength training opportunities. Strong and elastic muscles avoid injury and unnatural movement. Muscles stretch well, which minimizes the risk of injury.
  • Improves health. The movements performed during stretching help to avoid injuries to the articular apparatus and are an excellent prevention of immobilization. The result is a much better feeling.

For those engaged in strength training, stretching is even more important. It stimulates the growth of muscle fibers and strength indicators.

How to stretch correctly?

To maximize the benefits of stretching the tendons and muscles, it is not enough just to make the appropriate movements. The following rules must be followed and followed:

  • Stretch at the end of your workout. At the beginning of the session, the muscles are not yet sufficiently warmed up. This makes a strong stretch almost impossible, as pain is felt in the muscles. At such a moment, it is necessary to stop, and not reach through force. The painful sensation signals that the stretch is being done correctly, but it’s time to stop in the accepted position. At the beginning of the workout, even after warm-up, this position will be much less effective, since muscle pain is felt earlier than in well-warmed ones.
  • The delay time in the adopted position should be about half a minute. A smaller pause will no longer be quite effective.
  • It is necessary to adhere to the principle of gradualness. No sudden movements. Stretch slowly and carefully. You can’t do everything to the maximum right away. The result is consolidated and improved from training to training.
  • Sharp pain must not be allowed. It symbolizes the excessive tension of unprepared tendons and muscles, which can provoke injury. We’ll have to skip a couple of workouts. This will set back the progress achieved.
  • Before performing a movement, be sure to relax the target muscles, and only then begin to stretch. When a muscle is in good shape, it resists and stretches well. Pulling with force can cause serious injury.
  • Breathing is not critical. Breathe as it is most convenient for you. Above all, focus on the target muscle group.
  • For maximum results. You should pull exactly the muscle group that was trained in the lesson, with the exception of the legs and lower back. It is recommended to stretch the latter regularly.

It is best to stretch in front of a mirror.

Stretching technique for muscle groups

Stretching technique is paramount. Each muscle group requires its own thorough approach. Correct stretching of a particular part of the body allows you to achieve the desired result in the shortest possible time.

Neck

The basic exercise for stretching the muscles of the neck is tilting the head to the right-left, forward-backward.

  1. Take a starting position – just stand up straight. Look ahead of you. Slowly, without sudden movements, stretch your chin to the chest to the maximum, trying to lower your head as low as possible. This should hold for 10 to 15 seconds.
  2. Throw your head back, trying to reach the back of your back. Continue reaching for your back for 10-15 seconds. You cannot open your mouth. This will be cheating.
  3. Start stretching the side muscles of your neck. Take the starting position as before. Raise your right hand and pull your head to the right side. The main thing is not to allow shoulder displacement. When you feel tension, continue the movement a little more, linger in the accepted position for about 20-30 seconds.
  4. Repeat the movement from point 3, but on the opposite side of the neck, that is, pull your head towards your left shoulder with your left hand.
  5. Finally, make a few circular movements to the left and right.

Hands

To stretch the shoulder girdle, flexors, extensors, you must use either a wall bar or vertical support.

The shoulders and biceps are stretched as follows:

  1. Stand with your right side to the support. Keep your body and legs straight.
  2. Place the palm of your right hand on a stance. Do not bend your arm, but pull it back a little.
  3. Begin to rotate the body to the left, moving so that a stretch is felt in the right shoulder and bicep. Choose the optimal direction of movement yourself, based on your inner feelings.
  4. Stretch as much as you can, and then hold the final position for about half a minute.

Repeat the exercise on the other arm.

Triceps stretch is performed as follows:

  1. Raise your right arm and bend your elbow so that your right palm is near your left shoulder.
  2. Grasp your right elbow with your left hand and pull it gently to the left.
  3. Hold at the extreme point of maximum tension for 30 seconds and change sides.

Chest

The pectoral muscles with the shoulder girdle and biceps are stretched as follows:

  1. Lean on uneven bars or other support, assuming a position like you want to push up. At the same time, the feet are on the floor. Elbows raised high.
  2. Slowly lower yourself down as far as your pectoral muscles allow. The body should not sink too low, as this position can damage the ligament. Always aim for the soreness to be mild, but not excessive.
  3. Remain in this position for half a minute. You can start at 15-20, then work up to 30 seconds.

Abdominal muscles

To make your abdominal muscles more elastic and taut, stretch as follows:

  1. Lie on your stomach. Hands are placed as if you want to do push-ups.
  2. Straighten up as if you were doing push-ups. The pelvis should be pressed against the floor surface. Bend as much as possible. Hold this position for about 30 seconds.

When you feel severe back pain, bend not to this position, but to the most comfortable position. Then gradually you will be doing more deflection, stretching even better.

Back, lower back and back of the thighs

To stretch your upper back, follow these steps:

  1. Stand straight with your chest forward and your pelvis back. Try to breathe as evenly as possible. Begin to bend your back in the chest area to the maximum. The shoulder girdle is brought down in front. Stretch your arms forward and down. Move your chin behind your hands.
  2. Stretch your arms as much as you can, and then return to the starting position. There is no need to pause. Tension should be felt around the shoulder blades. When it is absent, try to move so that the stretch falls on these muscles.

The post Stretching your muscles after exercise first appeared on antiseizurepharm.com.

]]>
L-carnitine in sports https://antiseizurepharm.com/sports-nutrition/l-carnitine-in-sports/ https://antiseizurepharm.com/sports-nutrition/l-carnitine-in-sports/#respond Thu, 08 Jul 2021 14:08:50 +0000 https://antiseizurepharm.com/?p=764 Carnitine is important in cases where it is necessary to increase general and special endurance in aerobic sports (running, swimming, rowing, etc.) If an athlete is not concerned about reducing body weight, maximum energy gain can be achieved by combining levocarnitine with an increased amount of fat in the diet. There is a special high-fat… Read More »L-carnitine in sports

The post L-carnitine in sports first appeared on antiseizurepharm.com.

]]>
Carnitine is important in cases where it is necessary to increase general and special endurance in aerobic sports (running, swimming, rowing, etc.) If an athlete is not concerned about reducing body weight, maximum energy gain can be achieved by combining levocarnitine with an increased amount of fat in the diet. There is a special high-fat diet, which is prescribed simultaneously with large doses of carnitine. This method of strengthening bioenergetics is especially preferable when it is necessary to avoid a drop in body weight during training.

Levocarnitine helps to increase endurance in both aerobic and anaerobic (powerlifting, bodybuilding, etc.) sports. It should be noted that the anabolic effect of levocarnitine can be masked by a general drop in body weight as a result of the disappearance of subcutaneous fat and internal adipose tissue. Therefore, when evaluating the anabolic effect of carnitine, one should be guided by criteria other than such indicators as body weight and limb volume. In this case, this is the percentage of fat mass and total body weight.

To achieve maximum effect, levocarnitine should be used along with a well-balanced diet and training program. Levocarnitine is not doping and can be used in sports nutrition without any restrictions.

In the absence of initial synthesis disorders in the body, it is recommended to use short courses, since with prolonged use there is a withdrawal syndrome-the production of its own levocarnitine decreases and there is a need to constantly take an exopreparation.

L-Carnitine for muscle protection

A daily dose of 2 grams of L-carnitine protects the muscles of athletes from destruction, according to the results of a study by sports scientists of the Islamic Azad University in Iran, published in the Journal of Sports Medicine of Asia.

The researchers divided 22 physically active young people into two groups. One group took a placebo for two weeks. The other group took a supplement containing 2 g of L-carnitine. Two weeks later, the researchers conducted a test 15-minute run. The researchers also analyzed the blood of the subjects: before taking the supplement (Base), immediately before the race (Pre), immediately after the race (Post), after 2 hours (2H) and after 24 hours (24H).

Results

During the race, the concentration of markers of muscle destruction — the enzymes lactate dehydrogenase (LDH, LDH) and creatine kinase (CK) in the blood of the subjects increased, but this increase was noticeably lower in athletes taking carnitine. It turned out that L-carnitine reduces the degree of damage to muscle cells.

TBARS (a reactive compound of thiobarbituric acid-TBCRB) is a marker of free radical activity. These aggressive molecules, released during intense physical activity, can damage the structure of cells. During the race, the concentration of TBARS in the blood of the subjects increased, but the growth was noticeably lower in athletes who took L-carnitine.

Conclusion

A two-week oral intake of L-carnitine supplements has some softening effect on lipid peroxidation, damage to muscle cells and increases antioxidant activity. However, the exact mechanism of attenuation of oxidative stress markers by L-carnitine has not been established and requires further study.

The post L-carnitine in sports first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/l-carnitine-in-sports/feed/ 0
Functions and effects of L-carnitine https://antiseizurepharm.com/sports-nutrition/functions-and-effects-of-l-carnitine/ https://antiseizurepharm.com/sports-nutrition/functions-and-effects-of-l-carnitine/#respond Thu, 08 Jul 2021 14:04:15 +0000 https://antiseizurepharm.com/?p=763 Fat burning L-carnitine transports fatty acids (structural elements of fat) into the mitochondrial matrix, where they are destroyed with the release of energy. Additional intake of L-carnitine is carried out in the hope of intensifying the destruction of fats. Increase mental and physical energy According to the results of a double-blind placebo-controlled study conducted in… Read More »Functions and effects of L-carnitine

The post Functions and effects of L-carnitine first appeared on antiseizurepharm.com.

]]>
Fat burning

L-carnitine transports fatty acids (structural elements of fat) into the mitochondrial matrix, where they are destroyed with the release of energy. Additional intake of L-carnitine is carried out in the hope of intensifying the destruction of fats.

Increase mental and physical energy

According to the results of a double-blind placebo-controlled study conducted in 2007 in Italy, the administration of L-carnitine at a daily dose of 2 g for 6 months led to an increase in mental and physical activity. The subjects noted an improvement in mood, an increase in endurance and an increase in overall tone. In fairness, it should be noted that for most athletes, the results of this study are hardly indicative due to the fact that the subjects in it were 66 people aged from 100 to 106 (!) years.

Resistance to stress

ON L-Carnitine

Studies have proven the effectiveness of carnitine in increasing stress tolerance and increasing the adaptive capabilities of the human body.

Detoxification

L-carnitine supports the level of free coat, which is involved in the neutralization of organic acids and xenobiotics, is necessary for the functioning of certain enzymes and for the normal operation of the Krebs cycle.

Anabolic functions

The anabolic effect of L-carnitine was established experimentally, during experiments with the use of this supplement, scientists noticed that the subjects not only lost fat, but also increased lean muscle mass. The mechanism of this action is still not fully understood, but there are a number of theories that explain the anabolic effect of carnitine by its participation in phospholipid metabolism, optimization of the Acetyl-CoA/CoASH balance, greater use of fat as an energy source, and improved neurotransmission.
Reduces cholesterol

L-carnitine reduces harmful cholesterol, thereby preventing narrowing of the blood vessels of the heart and brain, prevents heart attacks and strokes.

Protects the heart and blood vessels

First of all, this effect is realized by reducing the level of cholesterol, which affects small coronary vessels. In addition, L-carnitine improves the metabolism of the myocardium, has an antioxidant effect. Clinical studies have shown that, after a course of carnitine, people with heart diseases complained less often, and the function of the myocardium improved.

Other effects

L-carnitine has neuroprotective, antihypoxic, antioxidant and antithyroid effects, prevents apoptosis and osteoporosis, and also stimulates tissue regeneration.

L-carnitine: harm and side effects
Read the main article: L-carnitine: harm and side effects

The effectiveness of the use of additional doses of L-carnitine is questioned by a number of researchers. Thus, according to the meta-analysis, the low effectiveness of L-carnitine in athletes was shown .For women who are overweight, the ineffectiveness of carnitine (4g/day) in combination with regular cardio loads (4×30 min/week) was shown.

L-carnitine in food

The content of L-carnitine in some foods
The main food sources of L-carnitine are meat, fish and dairy products. The daily norm of this substance (300 mg) is contained in about 300-400 g of raw beef, besides, during the heat treatment of meat, a significant part of levocarnitine is lost, this circumstance dictates the need to take carnitine in the form of additional additives.

The post Functions and effects of L-carnitine first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/functions-and-effects-of-l-carnitine/feed/ 0
Effects of creatine https://antiseizurepharm.com/sports-nutrition/effects-of-creatine/ https://antiseizurepharm.com/sports-nutrition/effects-of-creatine/#respond Thu, 08 Jul 2021 13:58:36 +0000 https://antiseizurepharm.com/?p=762 Increase in strength In bodybuilding, during the performance of high — intensity exercises, the need for ATP in working muscles increases significantly-hundreds of times higher compared to the resting state. Depleted reserves of ATP and phosphocreatine must be constantly replenished so that muscle contractions can continue at peak levels of frequency and strength. By increasing… Read More »Effects of creatine

The post Effects of creatine first appeared on antiseizurepharm.com.

]]>
Increase in strength

In bodybuilding, during the performance of high — intensity exercises, the need for ATP in working muscles increases significantly-hundreds of times higher compared to the resting state. Depleted reserves of ATP and phosphocreatine must be constantly replenished so that muscle contractions can continue at peak levels of frequency and strength. By increasing phosphocreatine by taking creatine monohydrate, you can increase the amount of ATP, and thus increases muscle strength.

Review of scientific data on creatine

Increase in muscle mass

It is not uncommon to add dry body weight from 2 to 5 kg for 1 month of admission, with systematic training and proper nutrition. Recent experiments prove that creatine monohydrate is able to increase the repeated maximum in the bench press by 10 kg after a week of taking it, improve sprinting abilities. Increasing the strength allows you to achieve maximum growth-stimulating effect on the muscles. However, it should be noted that taking creatine does not always have a similar effect. It can manifest itself much weaker due to the weak sensitivity of the body to creatine and be expressed only in a certain increase in efficiency without an increase in strength qualities.

Muscle quality

In addition, creatine also improves the relief of the muscles. Creatine monohydrate binds to water as it is absorbed into muscle cells. As more creatine is stored, more water is attracted to the muscle cell. This explains the hydrating effect of creatine on the muscle cell, which consists of approximately 75 percent water. Bodybuilders notice: a well-hydrated muscle looks fuller, more rounded and more pumped up.

Scientific studies show that when muscle cells increase their volume due to overhydration, protein synthesis increases, and the process of its breakdown is minimized (this can also enhance glycogen synthesis). This concept was first developed by researchers from EAS Anthony Almada and Ed Byrd, and is now widely accepted in the sports nutrition industry.

Increased secretion of anabolic hormones

Studies show that creatine can increase the secretion of endogenous anabolic hormones in response to training loads. These hormones are represented by somatotropin and testosterone. Moreover, the level of somatotropin increases only 2 hours after taking creatine. Such a delay may indicate that the release of somatotropic hormone does not depend on creatine itself, but is mediated and occurs as a result of a cellular response.

Also, studies have determined that the supplement increases the secretion of insulin-like growth factor by 15% compared to the placebo group. The formation of myostatin is significantly suppressed.

According to research by scientists from the University of Stellenbosch, South Africa, creatine increases the level of dihydrotestosterone – an androgenic metabolite of testosterone.

Lactic Acid Buffer

There is evidence that creatine also works as a lactic acid buffer. During intensive work in the anaerobic mode, the muscles secrete lactic acid, this substance is partially responsible for the burning sensation that occurs when the muscle works to failure. In recent studies conducted by Dr. Michael Prevost from Louisiana State University, the results (confirming the results of previous studies conducted by Dr. Hultman’s group in Sweden) show that creatine can restrain the release and action of lactic acid and improve recovery time after a short intense exercise (for example, strength training).

Other positive effects of creatine

Having analyzed in detail the main effects of creatine that are important in bodybuilding, I would also like to give a list of additional positive effects and benefits:

  • supplementation with creatine has a positive effect on reducing the total amount of cholesterol in plasma, triglycerides and very low-density lipoproteins (protection of the cardiovascular system);
  • creatine can have an anti-inflammatory effect in acute inflammation, local irritation and chronic inflammatory conditions (for example, arthritis);
  • the creatine / phosphocreatine system has a protective effect on the central nervous system in ischemia and in hypoxic conditions (with a lack of oxygen);
  • creatine supplementation is used to treat diseases that cause m
  • uscle atrophy, creatine depletion and neuromuscular disorders;
  • creatine is being investigated in the direction of possible useful properties for suppressing the growth of certain types of tumors in mammals. Some studies suggest that creatine may have some anti-cancer activity;
    supplementation with creatine has a positive effect on the athletic performance of vegetarians;
  • in chronic heart failure, the cardiac creatine level decreases; supplementation with creatine in patients with such symptoms increases the amount of energy-rich phosphocreatine in skeletal muscles and, consequently, performance in terms of strength and endurance. In fifty patients who underwent heart valve replacement surgery, creatine supplements reduced arrhythmia by 75%.

The post Effects of creatine first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/effects-of-creatine/feed/ 0
Forms of amino acids https://antiseizurepharm.com/sports-nutrition/forms-of-amino-acids/ https://antiseizurepharm.com/sports-nutrition/forms-of-amino-acids/#respond Thu, 08 Jul 2021 13:47:26 +0000 https://antiseizurepharm.com/?p=741 Amino acids are available in the form of powder, tablets, solutions, capsules, but all these forms are equivalent in effectiveness. There are also injectable forms of amino acids that are administered intravenously. Injecting amino acids is not recommended, since it has no advantages over oral administration, but there is a high risk of complications and… Read More »Forms of amino acids

The post Forms of amino acids first appeared on antiseizurepharm.com.

]]>
Amino acids are available in the form of powder, tablets, solutions, capsules, but all these forms are equivalent in effectiveness. There are also injectable forms of amino acids that are administered intravenously. Injecting amino acids is not recommended, since it has no advantages over oral administration, but there is a high risk of complications and adverse reactions.

When to take amino acids

When gaining muscle mass, it is most advisable to take amino acids only before and after training, as well as (optionally) in the morning, since at these moments a high rate of amino acid intake is required. At other times, it is more reasonable to take protein. When losing weight, amino acids can be taken more often: before and after training, in the morning and in between meals, since the purpose of their use is to suppress catabolism, reduce appetite and preserve muscles.

Optimal doses

Amino acids in bodybuilding are used in a very wide range of doses. It is desirable that a single dose should be at least 5 g, although the maximum result is achieved when using 10-20 g once. When buying amino acid complexes, pay attention to the dose sizes of the supplement. Some manufacturers make the doses very low in order to increase the cost per unit weight of the product.

Combination with other additives

Amino acids can be combined with all types of sports nutrition, but they can not always be mixed (drunk at the same time). “Attention” Do not take together amino acid complexes with protein, gainer, food substitute or food, as this reduces the speed of their assimilation, which means that the meaning of their use is lost! Carefully read the manufacturer’s recommendations.

Amino acid complexes differ in their composition, the ratio of amino acids and the degree of hydrolysis. Amino acids in free form, usually isolated (glutamine, arginine, glycine, and others), but there are also complexes. Hydrolysates are broken proteins that contain short amino acid chains that can be quickly absorbed. Di-and tripeptide forms are essentially also hydrolysates, only the chains of amino acids are shorter, and consist of 2 and 3 amino acids, respectively, are absorbed very quickly. BCAA is a complex of three amino acids-leucine, isoleucine and valine, which are most in demand in the muscles, are absorbed very quickly.

“Attention” confuses many people when the manufacturer specifies a protein hydrolysate in the composition or description, so there are often statements that it is actually a “pressed protein”. However, the study showed that hydrolyzed protein is absorbed faster than free forms of amino acids. This is probably due to the fact that di – and tripeptides require fewer active substances-transporters in the gastrointestinal tract.

The post Forms of amino acids first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/forms-of-amino-acids/feed/ 0
Amino acids in bodybuilding https://antiseizurepharm.com/sports-nutrition/amino-acids-in-bodybuilding/ https://antiseizurepharm.com/sports-nutrition/amino-acids-in-bodybuilding/#respond Thu, 08 Jul 2021 13:37:49 +0000 https://antiseizurepharm.com/?p=750 Scientists have found that amino acids are extremely important for muscle recovery after training, muscle preservation during the drying cycle or weight loss, as well as muscle growth. BCAAs play a special role in bodybuilding. Muscle tissue consists of 35% of them, BCAAs have a large number of biological effects, and are available separately. Even… Read More »Amino acids in bodybuilding

The post Amino acids in bodybuilding first appeared on antiseizurepharm.com.

]]>
Scientists have found that amino acids are extremely important for muscle recovery after training, muscle preservation during the drying cycle or weight loss, as well as muscle growth. BCAAs play a special role in bodybuilding. Muscle tissue consists of 35% of them, BCAAs have a large number of biological effects, and are available separately.

Even moderate-intensity exercise leads to the consumption of 80% of all free amino acids-this underlines the importance of amino acid supplements for rapid recovery and further muscle growth.

Amino acids in foods and supplements (equivalent content)

Effects of amino acids

An energy source. Amino acids are metabolized in a different way than carbohydrates, so the body can receive much more energy during training if the amino acid pool is full.
Acceleration of protein synthesis. Amino acids stimulate the secretion of the anabolic hormone – insulin, and also activate mTOR, these two mechanisms are able to trigger muscle growth. The amino acids themselves are used as a building material for proteins.
Suppression of catabolism. Amino acids have a pronounced anti-catabolic effect, which is especially necessary after training, as well as during the weight loss or drying cycle.
Fat burning. Amino acids promote fat burning due to the expression of leptin in adipocytes by
Evaluation of the benefits

Useful information for beginners

There is no doubt that amino acids are very important and useful in bodybuilding, however, as already mentioned above, protein consists of the same amino acids, it is protein that fills the need for amino acids in all people. Amino acids, as a sports supplement, differ from protein only by a higher rate of assimilation, and it is required only during and immediately after training, as well as in the morning. In addition, amino acids can be useful for weight loss, since they contain few calories, at the same time they inhibit catabolism well, reduce appetite and preserve muscles.

A significant disadvantage of amino acids is the high cost and small doses. If you do not experience financial restrictions, you can take 10 g of amino acids 4 times a day, and get good results. On the other hand, you can take 20 g of protein 4 times a day and you will get almost the same results in gaining muscle mass, as well as save 80% of money.

“Attention” Output

Complex amino acids have few advantages over whey protein, and also lag behind (at the same time have a higher cost) from protein hydrolysate. Both when gaining muscle mass and when losing weight, give preference to protein and BCAA amino acids.

Types of amino acids

Amino acid complexes differ in their composition, the ratio of amino acids and the degree of hydrolysis. Amino acids in free form, usually isolated (glutamine, arginine, glycine, and others), but there are also complexes. Hydrolysates are broken proteins that contain short amino acid chains that can be quickly absorbed. Di-and tripeptide forms are essentially also hydrolysates, only the chains of amino acids are shorter, and consist of 2 and 3 amino acids, respectively, are absorbed very quickly. BCAA is a complex of three amino acids-leucine, isoleucine and valine, which are most in demand in the muscles, are absorbed very quickly.

The post Amino acids in bodybuilding first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/amino-acids-in-bodybuilding/feed/ 0
Why do they take a gainer? https://antiseizurepharm.com/sports-nutrition/why-do-they-take-a-gainer/ https://antiseizurepharm.com/sports-nutrition/why-do-they-take-a-gainer/#respond Thu, 08 Jul 2021 13:29:12 +0000 https://antiseizurepharm.com/?p=739 Gainer (from the English gain-gain) is a class of sports nutrition, which is a protein-carbohydrate mixture. Sometimes manufacturers add creatine, vitamins, trace elements, amino acids, etc. ingredients. Also, the gainer often contains a small amount of fat. The main function of the gainer is to increase body weight and quickly replenish energy reserves. The effectiveness… Read More »Why do they take a gainer?

The post Why do they take a gainer? first appeared on antiseizurepharm.com.

]]>
Gainer (from the English gain-gain) is a class of sports nutrition, which is a protein-carbohydrate mixture.

Sometimes manufacturers add creatine, vitamins, trace elements, amino acids, etc. ingredients. Also, the gainer often contains a small amount of fat. The main function of the gainer is to increase body weight and quickly replenish energy reserves. The effectiveness of combining protein and carbohydrates in bodybuilding has been proven in several independent studies.

The history of the gainer is quite long, it is one of the first sports supplements. In the past, gainers were produced using cheap types of proteins, loaded with sugar and fats to maximize the caloric content. One serving of such a gainer could contain up to 3000 kilocalories. The quality of the protein left much to be desired. Surprisingly, even now you can find such sports nutrition in Russia, nevertheless, high-quality, balanced gainers have appeared on the market, which contain purified protein with high biological value, contain special carbohydrates and many other useful substances.

Why do they take a gainer?

The gainer is designed for people of a lean physique or ectomorphs, without problematic fat deposition, who seek to add body weight in a short time. If you add three servings of this sports supplement to your usual diet and systematically engage in bodybuilding, then your weight will begin to grow steadily. For people with a fast rate of metabolic reactions, this is sometimes not enough, so you have to include additional sports supplements and raise the calorie content of the daily diet. People who are prone to fullness or endomorphs are not recommended to take a gainer, since most of the carbohydrates will be deposited in adipose tissue, so it is more reasonable for them to consider protein mixtures as an additive, and consume mainly slow carbohydrates.
Also, the gainer is well suited for track and field athletes, boxers, football players, basketball players and other athletes who are subjected to prolonged aerobic loads. The use of a gainer before exercise allows you to maintain a high level of energy during classes and games, and after training helps to restore strength and muscles. If you follow the right diet and the regime of taking a gainer, then you can easily maintain the weight at the right level. Modern gainers are well suited not only for increasing muscle mass, but also as energy and restorers.

How to take a gainer

In bodybuilding, the most appropriate time to take a gainer is a few minutes after the training. At this moment, the so-called protein-carbohydrate window opens, which can fully close the gainer. This will allow the athlete to quickly restore strength, regenerate muscle tissue, suppress catabolic processes and replenish depleted energy reserves.
You can also take a gainer before training. The advantage of this moment of time is that the body will receive an energy substrate-carbohydrates, which will allow you to train more intensively and for a longer time, and a high concentration of amino acids will suppress catabolism from the very beginning of training. However, there is a significant drawback in this — during the training there will be no fat loss, and the probability of its increase will increase.
Some recommend taking a gainer at other times, two, three or even four times a day. There is a reasonable reason for this, if you want to increase your weight as quickly as possible and are not at all inclined to fullness, otherwise you risk gaining weight mainly due to fat. It is much more reasonable to take 1 gainer once, the remaining 2-3 doses should fall on protein.On average, each serving of a gainer contains: 20-40 g of protein, 50-80 g of carbohydrates and several grams of unsaturated fats. The amounts of other substances vary depending on the brand of the product. Do not exceed the doses recommended by the manufacturer, since large amounts simply will not be fully absorbed. In preparation, the gainer is quite simple: a portion of dry powder is stirred in milk or water, after which it is ready for use.

Combination with other sports nutrition

The gainer is perfectly combined with creatine. Carbohydrates and proteins included in it help creatine to be absorbed better and faster. They can be mixed in one cocktail and taken after the training.
In addition, to make bodybuilding as productive as possible, it is also advisable to take a protein, a pre-workout complex and a vitamin and mineral complex. It is perfectly combined with anabolic complexes.
Never take a gainer during drying cycles, losing weight and working on relief.

The post Why do they take a gainer? first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/why-do-they-take-a-gainer/feed/ 0
Protein in bodybuilding https://antiseizurepharm.com/sports-nutrition/protein-in-bodybuilding/ https://antiseizurepharm.com/sports-nutrition/protein-in-bodybuilding/#respond Thu, 08 Jul 2021 13:22:54 +0000 https://antiseizurepharm.com/?p=738 Protein is a sports supplement that is made on the basis of protein mixtures. In the digestive tract, protein is broken down by enzymes to amino acids, which are absorbed into the blood and then used by muscles and other tissues. In a broader sense, a protein (protein, polypeptides) is an organic substance consisting of… Read More »Protein in bodybuilding

The post Protein in bodybuilding first appeared on antiseizurepharm.com.

]]>
Protein is a sports supplement that is made on the basis of protein mixtures. In the digestive tract, protein is broken down by enzymes to amino acids, which are absorbed into the blood and then used by muscles and other tissues.

In a broader sense, a protein (protein, polypeptides) is an organic substance consisting of amino acids connected to a chain by a covalent bond and forming a polypeptide. It is proteins that form the basis of muscle tissue and are a key dietary component. Muscle growth is possible only when a positive nitrogen balance is created in the body. In addition, protein in bodybuilding is understood as a type of sports nutrition, which consists of concentrated protein.

The functions of the body’s proteins are very diverse. Proteins-enzymes provide the flow of biochemical reactions and play an important role in metabolism. Some proteins perform a structural or mechanical function, forming a cytoskeleton that supports the shape of cells. Proteins also play an important role in the signaling systems of cells, in the immune response and in the cell cycle. In bodybuilding, the main importance is attached to the contractile function of proteins — all voluntary and involuntary movements are made due to the interaction of protein molecules.

Types of protein and tricks of producers

Given the variety of functions and biological effects of protein and its components — amino acids, in bodybuilding, proteins are used for various purposes: to reduce body fat, to stimulate muscle growth, as well as to maintain a healthy physical shape. Let’s take a closer look at the functions of proteins that are relevant for a specific sports activity and all the issues of their application.

Food sources of protein
Proteins in food products
Protein products
Protein dishes (recipes)
Types of protein

Rating of different types of protein
Types of proteins by origin
Types of proteins by absorption rate and composition:
Complex protein
Slow protein-casein
Fast protein-whey
Verification of authenticity

A simple method of verifying the authenticity of a protein is widely used by pouring it with boiling water, sometimes followed by boiling, as a result of which a denaturation process is observed with the formation of characteristic flakes and precipitation. To enhance the reaction, it is desirable to add a few drops of vinegar to lower the pH of the solution and neutralize the negative charge.

Benefits for the cardiovascular system

It was found that people who consume whey protein are 8% less likely to develop heart disease. The researchers found a decrease in the value of both systolic and diastolic blood pressure during the 24-hour period after taking the supplement. The levels of cholesterol and triglycerides, fats contained in the blood, which are known to increase the risk of developing cardiovascular diseases, also decreased. Lead researcher Agnes Fekete, from the University of Reading, said: “The results of this study are very interesting. This shows the positive effect that milk proteins can have on blood pressure. Long-term studies show that people who drink more milk tend to be healthier, but until now there has been no work evaluating how milk proteins affect blood pressure.”

Benefits for immunity

The composition of whey protein includes: beta-lactoglobulin, alpha-lactalbumin, bovine serum albumin, lactoferrin, immunoglobulins (for example, IgA), lactoperoxidase enzymes, glycomacropeptides, vitamins (such as vitamin D) and minerals such as Ca2+. Lactoferrin and lactoferricin exhibit antimicrobial activity; lysosomes, lactoperoxidase, various globulins and peptides also contribute to immune protection.

The post Protein in bodybuilding first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/protein-in-bodybuilding/feed/ 0
Fat burning and weight gain at the same time https://antiseizurepharm.com/sports-nutrition/fat-burning-and-weight-gain-at-the-same-time/ https://antiseizurepharm.com/sports-nutrition/fat-burning-and-weight-gain-at-the-same-time/#respond Thu, 08 Jul 2021 13:12:38 +0000 https://antiseizurepharm.com/?p=720 Burning fat and gaining muscle mass at the same time is the most frequent dream of novice bodybuilders and, perhaps, the most frequent question of readers. For 90% of people, it is impossible without the use of anabolic steroids and other powerful pharmacological agents. The remaining 10% of people who are able to do this… Read More »Fat burning and weight gain at the same time

The post Fat burning and weight gain at the same time first appeared on antiseizurepharm.com.

]]>
Burning fat and gaining muscle mass at the same time is the most frequent dream of novice bodybuilders and, perhaps, the most frequent question of readers. For 90% of people, it is impossible without the use of anabolic steroids and other powerful pharmacological agents. The remaining 10% of people who are able to do this have genetically determined physiological advantages (mutation of the myostatin gene, increased secretion of growth hormone and testosterone), and they are not even looking for such articles, because they are not interested in the theoretical basis of training, since they are able to achieve good results of body building without using complex training programs, sports nutrition and a strict diet.

It is not surprising why most beginners fail to achieve simultaneous fat burning and muscle gain. We need to change the strategy and act consistently:

  • Reduce the percentage of body fat to the norm (about 15%) – measurements can be performed using Body Expert
  • Gain muscle mass
  • Work on the terrain

A leading expert in the fitness industry – Lyle McDonald in his note Adding Muscle While Losing Fat (eng.) notes the ability to achieve body recomposition (as in the United States they call simultaneous fat burning and muscle growth) by beginners, especially those who have solid fat reserves.

McDonald says that when people are just starting to work out with weights, their strength indicators and muscle mass grow rapidly under any conditions. All this is explained by a simple logic – previously untrained beginners have an untapped potential for increasing strength and muscle mass.

Based on his observations, McDonald concludes that beginners are able to grow muscle tissue even on a calorie deficit (due to which fat tissue is lost) – because previously their muscles did not receive an incentive for growth.

Another case that McDonald talks about is people returning to strength training after a long break. During the break in strength training, not only strength indicators decrease in people who have been engaged before, but also part of the muscle tissue is lost due to the fact that the muscles have not received a training stimulus for a long time to maintain their volumes (not to mention growth). In addition, during the break, the percentage of body fat in people who have given up training increases. As a result, a person who refused to train for a long time took a few steps back and thus freed up space in an almost filled jug.

In the “Korean Journal of Physiology and Pharmacology” in 2014, a study was published showing that the participants of the experiment who took ursolic acid as a supplement and regularly worked out in the gym for 8 weeks gained an average of 1.17 kg of muscle mass and lost 3 kg of fat.

Even more impressive results were announced in the journal “Clinical Endocrinology and Metabolism” in July 2013. In particular, scientists studied how testosterone injections affect fat deposits in the body of non-training men. All participants of the experiment were on the same diet, the energy value of which was 35.82 kilocalories and 1.3 grams of protein per kilogram of body weight per day. That is, a 100-kilogram man consumed 3,582 calories and 130 grams of protein. After 20 weeks, the participants of the experiment, who received injections of testosterone 300 mg and 600 mg per week, increased their dry muscle mass by 10 and 17%, respectively, while reducing the total amount of adipose tissue by 10%.

There are a lot of such studies and none of the scientists has ever been surprised by the fact of changes in the composition of the body, expressed in the growth of dry muscle mass and loss of fat mass. This is normal, it is natural for the human body and especially for a physically active person. It is only necessary to understand that such changes are possible only within certain, rather limited limits. Of course, when a person radically hits the mass set, eating a bunch of extra calories, then there can be no question of any fat loss. A similar situation is with “drying”. Trying to lose 10 kg of fat in a month, it is unlikely that with the necessary level of energy deficiency for such a result, we will also be able to increase the “meat”. But the fact remains. It is possible to grow muscles and burn fat at the same time. Under certain conditions, on a limited scale.

The post Fat burning and weight gain at the same time first appeared on antiseizurepharm.com.

]]>
https://antiseizurepharm.com/sports-nutrition/fat-burning-and-weight-gain-at-the-same-time/feed/ 0